Boron Neutron Capture Therapy

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Boron agentsron agentsentsResearch Center for Boron Neutron Capture TherapyStructure of oncotropic 10B moleculesBSH2Na+2－SHSttfti10Bll:10BH:10BBSH (disodium mercaptoundecahydro- dodecaborate)Another boron compound that is used in clinical research is BSH, which consists of a series of boron clusters with a unique 20-facet structure. BSH, a water-soluble ionic mole-cule with 12 boron atoms, reacts efficiently with neutrons and, because it can pass through the blood-brain barrier, was initially used to treat brain tumors. While BSH’s tumor selectivity (T/N ratio) and propensity to accumulate inside cells are low, reports indicate that it has exhibits a tendency to be distributed in the vicinity of tumor tissue. Currently, combination treatments are being developed to take advantage of the respective advantages of BPA and BSH.3Trends in the development of new 10B compoundsReports in scientific literature detail the synthesis of various boron compounds with the goal of developing effective new boron compounds. Most consist of oncotropic molecules that have been modified with 10B. Drug delivery systems (DDSs) targeting the comparatively large gaps between capillaries that characterize tumor tissue are also under active development.4The Research Center for Boron Neutron Capture Thera-py was recently established on Osaka Prefecture University’s Nakamozu Campus. The facility, which is equipped with state-of-the-art equipment and systems, is hosting initiatives including trial projects centering on the development of new boron compounds and associ-ated human resources development programs.A facility dedicated to developing boron compounds10B atomsOncotropicorganic molecule11001100B-B--Bboboobbriiririccc aacacacidididd,,BBbbiiiddbooborooronncllclclcusususstteteterr,,eettctc.Ammino oacids,s, cid, nuclcleieic cacids,s,ffoolic acidpoporphyrin, etc.10

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