Osaka Prefecture University

Development of an intracellular delivery system based on exosomes

LastUpDate: July 01, 2015

Development of an intracellular delivery system based on exosomes (vesicles secreted by cells) and success in efficiently killing cancer cells

Dr Ikuhiko Nakase (N2RC, Osaka Prefecture University) and Prof Shiroh Futaki (Institute for Chemical Research, Kyoto University) have developed an effective intracellular delivery system based on exosomes, vesicles secreted from cells that play a crucial role in cell-to-cell communication. It is a ground-breaking technique that can efficiently deliver drugs trapped in exosomes to cells by a very simple method using lipids and peptides. This technique could also be used to efficiently kill cancer cells by using exosomes containing anti-cancer proteins. The method will have wide application in biology, including assessing the activities of exosomal contents and developing candidate tools enabling intracellular visualization and cellular regulation for future therapeutic applications.

The results of this research were published in the on-line open-access journal Scientific Reports (Nature Publishing Group), May 26, 2015.

Combined treatment with a pH-sensitive fusogenic peptide and cationic lipids achieves enhanced cytosolic delivery of exosomes

Contact:

Nanoscience and Nanotechnology Research Center

Dr. Ikuhiko Nakase

E-mail i-nakase[at]21c.osakafu-u.ac.jp *Please change [at] to @.